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Klasyfikacja zawodników MotoGP w sezonie 2021 po TT Assen:
| 1 | Fabio QUARTARARO | Yamaha | FRA | 156 |
| 2 | Johann ZARCO | Ducati | FRA | 122 |
| 3 | Francesco BAGNAIA | Ducati | ITA | 109 |
| 4 | Joan MIR | Suzuki | SPA | 101 |
| 5 | Jack MILLER | Ducati | AUS | 100 |
| 6 | Maverick VIÑALES | Yamaha | SPA | 95 |
| 7 | Miguel OLIVEIRA | KTM | POR | 85 |
| 8 | Aleix ESPARGARO | Aprilia | SPA | 61 |
| 9 | Brad BINDER | KTM | RSA | 60 |
| 10 | Marc MARQUEZ | Honda | SPA | 50 |
| 11 | Takaaki NAKAGAMI | Honda | JPN | 41 |
| 12 | Pol ESPARGARO | Honda | SPA | 41 |
| 13 | Franco MORBIDELLI | Yamaha | ITA | 40 |
| 14 | Alex RINS | Suzuki | SPA | 33 |
| 15 | Alex MARQUEZ | Honda | SPA | 27 |
| 16 | Enea BASTIANINI | Ducati | ITA | 27 |
| 17 | Danilo PETRUCCI | KTM | ITA | 26 |
| 18 | Jorge MARTIN | Ducati | SPA | 23 |
| 19 | Valentino ROSSI | Yamaha | ITA | 17 |
| 20 | Luca MARINI | Ducati | ITA | 14 |
| 21 | Iker LECUONA | KTM | SPA | 13 |
| 22 | Stefan BRADL | Honda | GER | 11 |
| 23 | Lorenzo SAVADORI | Aprilia | ITA | 4 |
| 24 | Michele PIRRO | Ducati | ITA | 3 |
| 25 | Tito RABAT | Ducati | SPA | 1 |
| 26 | Garrett GERLOFF | Yamaha | USA |