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Klasyfikacja zawodników MotoGP w sezonie 2021 po GP Ameryk:
| 1 | Fabio QUARTARARO | Yamaha | FRA | 254 |
| 2 | Francesco BAGNAIA | Ducati | ITA | 202 |
| 3 | Joan MIR | Suzuki | SPA | 175 |
| 4 | Jack MILLER | Ducati | AUS | 149 |
| 5 | Johann ZARCO | Ducati | FRA | 141 |
| 6 | Brad BINDER | KTM | RSA | 131 |
| 7 | Marc MARQUEZ | Honda | SPA | 117 |
| 8 | Aleix ESPARGARO | Aprilia | SPA | 104 |
| 9 | Maverick VIÑALES | Aprilia | SPA | 98 |
| 10 | Miguel OLIVEIRA | KTM | POR | 92 |
| 11 | Jorge MARTIN | Ducati | SPA | 82 |
| 12 | Alex RINS | Suzuki | SPA | 81 |
| 13 | Enea BASTIANINI | Ducati | ITA | 71 |
| 14 | Takaaki NAKAGAMI | Honda | JPN | 70 |
| 15 | Pol ESPARGARO | Honda | SPA | 70 |
| 16 | Alex MARQUEZ | Honda | SPA | 54 |
| 17 | Franco MORBIDELLI | Yamaha | ITA | 40 |
| 18 | Iker LECUONA | KTM | SPA | 38 |
| 19 | Danilo PETRUCCI | KTM | ITA | 37 |
| 20 | Luca MARINI | Ducati | ITA | 30 |
| 21 | Valentino ROSSI | Yamaha | ITA | 29 |
| 22 | Stefan BRADL | Honda | GER | 13 |
| 23 | Michele PIRRO | Ducati | ITA | 8 |
| 24 | Dani PEDROSA | KTM | SPA | 6 |
| 25 | Lorenzo SAVADORI | Aprilia | ITA | 4 |
| 26 | Andrea DOVIZIOSO | Yamaha | ITA | 3 |
| 27 | Tito RABAT | Ducati | SPA | 1 |
| 28 | Cal CRUTCHLOW | Yamaha | GBR | |
| 29 | Garrett GERLOFF | Yamaha | USA | |
| 30 | Jake DIXON | Yamaha | GBR |